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In a group of diabetic patients insulin deficiency was registered in all of them when they underwent heparin therapy as a part of hemoperfusion therapy. When insulin therapy in the course of hemoperfusion therapy was performed insulin deficiency was also registered. However, when insulin therapy was started immediately after completion of hemoperfusion therapy insulin deficiency was absent. The possible reasons of the insulin deficiency during the hemoperfusion therapy are discussed.Inhibition of protein kinase C induces apoptosis and alters cytoskeleton in mouse thymocytes.

To examine the role of protein kinase C (PKC) in apoptosis and cell morphogenesis, we used the PKC inhibitor RO-31-8220 to examine cellular events in different stages of thymocyte maturation. RO-31-8220 induced apoptosis in 20% of the thymocytes cultured from 12-15 day old mice, with an additional 8% exhibiting