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This report presents a 33-year-old female receiving a second renal transplantation for secondary amyloidosis who developed lupus nephritis in the transplanted organ. Due to this, plasmapheresis with dextran sulfate cellulose (DSC) and high-dose pulse cyclophosphamide were performed. Plasmapheresis is a therapeutic measure that can be used in the treatment of life-threatening conditions. It is considered a non-invasive method that does not require intensive care of the patient. Here, we describe the clinical case of a patient who received DSC plasmapheresis in order to decrease the complications of the disease. We present a complete description of the pre- and post-operative course. Plasmapheresis with DSC could be considered a beneficial measure for resistant cases of lupus nephritis, although it is still under debate whether this therapy, depending on the patient’s condition, will be enough to avoid eventual graft failure.export const STOP = ‘STOP’;

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