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Neuroimaging studies on gambling and addictions have identified a bilateral network of regions activated when gambling is presented, and a network of regions deactivated during craving, withdrawal, and after extinction. The ventral striatum, anterior cingulate, and amygdala are involved in immediate non-reward processes; dorsal anterior cingulate in the anticipation and expectation of rewards; orbitofrontal and ventral tegmental in the anticipation of negative consequences; and orbitofrontal and dorsal frontal and parietal in the anticipation of positive consequences.

Video poker is a family of card games in which each player is dealt a hand of cards and the player makes a wager based on the value of the cards. As in most casino games, video poker games reward the player for a wide variety of circumstances. For example, a player might be rewarded for having a pair of tens, for a straight, a five of a kind, a full house, a large straight, or a flush.

In American video poker games, players are rewarded for a straight, a flush, or a royal flush, and for a hand that has three of a kind or four of a kind, although many casino games will present a straight or flush reward to the player for either. However, in multi-hand video poker games, only one player is dealt a particular hand;